药品说明书是各国主管部门批准的法定文件，美国FDA批准的别嘌醇片说明书和中国通过一致性评价的别嘌醇片说明书中药理毒理部分均有相关描述。英文原文：“The renal clearance of hypoxanthine and xanthine is at least 10 times greater than that of uric acid. The increased xanthine and hypoxanthine in the urine have not been accompanied by problems of nephrolithiasis.”中文原文：“次黄嘌呤和黄嘌呤的肾清除率是尿酸的至少10倍。尿液中黄嘌呤和次黄嘌呤的增加并未伴随肾结石的问题。”

德国上市的别嘌醇片有一段是这样说的：“Xanthine depositionIn conditions where the rate of urate formation is greatly increased (e.g. malignant disease and its treatment, Lesch Nyhan Syndrome) the absolute concentration of xanthine in urine could, in rare cases, rise sufficiently to allow deposition in the urinary tract. This risk may be minimised by adequate hydration to achieve optimal urine dilution.”
大意就是说：
黄嘌呤沉积
在尿酸盐形成率大大增加的情况下（例如恶性疾病及其治疗，Lesch-Nyhan综合征），尿液中黄嘌呤的绝对浓度在极少数情况下可能会上升到足以在尿路中沉积。通过充分水合以实现最佳尿液稀释，可以将这种风险降至最低。