The original cardiovascular studies by Upjohn Pharmaceutical Company indicated that the slope of the dose response relationship of oral minoxidil was proportional to the extent of the hypertension and diminishes to zero at a supine diastolic blood pressure of approximately 85 mm Hg. *Therefore, while topical minoxidil was never expected to reduce a normal blood pressure, it may be contraindicated in the hypertensive patient until further data is available.
Upjohn制药公司在最初对米诺地尔的心血管研究中表明,口服米诺降血压的剂量斜率和高血压的严重程度成正比,舒张压大概在85毫米汞柱时斜率为零。因此从来没有人期望外用米诺地尔可以降血压,外用治疗脱发可能在大数据研究结果出来之前,禁止高血压患者使用。