文章提到: During 6 months of follow-up, blood pressure did not change, whereas minoxidil increased heart rate by 3-5 beats min-1. 经过六个月的跟踪研究,外用米诺并没有引起血压的变化,倒是使得心跳每分钟增加了3-5次。
2018年一篇发表在American Journal of Physiology Heart & Circulatory Physiology期刊上的学术论文【6】Minoxidil improves vascular compliance, restores cerebral blood flow and alters extracellular matrix gene expression in a model of chronic vascular stiffness(米诺地尔可改善血管弹性,恢复脑部供血,并在慢性血管僵硬模型中改变细胞外基质基因表达)似乎又发现了米诺地尔在治疗心脑血管疾病方面的新作用,这似乎对米诺地尔更多的应用提供了理论基础
参考文献: 【1】O'Malley K, Mcnay J L. A method for achieving blood pressure control expeditiously with oral minoxidil[J]. Clinical Pharmacology & Therapeutics, 1975, 18(1):39-44.
【2】Vanderveen E E, Ellis C N, Kang S, et al. Topical minoxidil for hair regrowth.[J]. Journal of the American Academy of Dermatology, 1984, 11(3):416-421.