Neuron-glia interactions in the pathophysiology of epilepsy
神经元 - 神经胶质相互作用在癫痫的病理生理学中
摘要：
Epilepsy is a neurological disorder afflicting ~65 million people worldwide. It is caused by aberrant synchronized firing of populations of neurons primarily due to imbalance between excitatory and inhibitory neurotransmission. Hence, the historical focus of epilepsy research has been neurocentric. However, the past two decades have enjoyed an explosion of research into the role of glia in supporting and modulating neuronal activity , providing compelling evidence of glial involvement in the pathophysiology of epilepsy. The mechanisms by which glia, particularly astrocytes and microglia, may contribute to epilepsy and consequently could be harnessed therapeutically are discussed in this Review.
癫痫是一种神经系统疾病，折磨全世界约6500万人。它是由神经元群体的异常同步激发引起的，主要是由于兴奋性和抑制性神经传递之间的不平衡。因此，癫痫研究的历史重点是神经中心。然而，在过去的二十年里，人们对胶质细胞在支持和调节神经元活动中的作用进行了大量研究，提供了胶质参与癫痫病理生理学的令人信服的证据。本综述讨论了胶质细胞，尤其是星形胶质细胞和小胶质细胞可能导致癫痫并因此可以在治疗上进行治疗的机制。
神经元 - 神经胶质相互作用在癫痫的病理生理学中
摘要：
Epilepsy is a neurological disorder afflicting ~65 million people worldwide. It is caused by aberrant synchronized firing of populations of neurons primarily due to imbalance between excitatory and inhibitory neurotransmission. Hence, the historical focus of epilepsy research has been neurocentric. However, the past two decades have enjoyed an explosion of research into the role of glia in supporting and modulating neuronal activity , providing compelling evidence of glial involvement in the pathophysiology of epilepsy. The mechanisms by which glia, particularly astrocytes and microglia, may contribute to epilepsy and consequently could be harnessed therapeutically are discussed in this Review.
癫痫是一种神经系统疾病，折磨全世界约6500万人。它是由神经元群体的异常同步激发引起的，主要是由于兴奋性和抑制性神经传递之间的不平衡。因此，癫痫研究的历史重点是神经中心。然而，在过去的二十年里，人们对胶质细胞在支持和调节神经元活动中的作用进行了大量研究，提供了胶质参与癫痫病理生理学的令人信服的证据。本综述讨论了胶质细胞，尤其是星形胶质细胞和小胶质细胞可能导致癫痫并因此可以在治疗上进行治疗的机制。
