Statins act by competitively binding to the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, HMGCR) and blocking the conversion of HMG-CoA to mevalonate, the rate-limiting step of cholesterol biosynthesis. ——Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol, Jiang et. al., Nature Communications, 2018 这一句话跨了四行……论是什么给了我本期夜话的灵感