本剧中司马懿的敌人有很多，按照“让子弹飞”里的台词：看来各位兄弟都是身怀绝技的人啊。
早期敌人：曹操、杨修
中期敌人：曹真、曹叡
后期敌人：曹爽、丁谧、何晏
----------------------------------------------只要是想杀司马懿的主角，就算作敌人吧---------------------------------
曹操的人设堪称完美，有血有肉，有私心有大义。皇叔的演技精湛，让人看完甚是解渴。
杨修的人设也算完美，有颜有脑，有心机有心计。翟天临的演出虽然有点过，但在同龄演员里亦算翘楚。
曹真的人设不算完美，有勇无谋，历史上的曹真也算数得上的名将，在本剧为了突出司马懿，太委屈曹真了。
曹叡的人设几近完美，时而镇定自若时而西斯底里，时而肝胆俱裂时而从容不迫。刘欢本剧演出堪比皇叔级别。
丁谧、何晏2位是配角，人设无功无过，演技食似鸡肋。
何驸马的演出还是容易让人跳戏。丁尚书中规中矩让人想到最早版本三国的标准演出，像一位古人。
曹爽，官拜大将军，曹氏氏族领袖，一人之下万人之上········································································································································································································································································································但是为什么他脑门上写着我无能，我贪婪，我没本事，我是官二代·············································································真的不配当仲达的对手，但又是这个不配当对手的对手把仲达逼的最惨·········这样的设定让我觉得司马二打赢了曹爽是应该的，没有那种胜利的酣畅··········
早期敌人：曹操、杨修
中期敌人：曹真、曹叡
后期敌人：曹爽、丁谧、何晏
----------------------------------------------只要是想杀司马懿的主角，就算作敌人吧---------------------------------
曹操的人设堪称完美，有血有肉，有私心有大义。皇叔的演技精湛，让人看完甚是解渴。
杨修的人设也算完美，有颜有脑，有心机有心计。翟天临的演出虽然有点过，但在同龄演员里亦算翘楚。
曹真的人设不算完美，有勇无谋，历史上的曹真也算数得上的名将，在本剧为了突出司马懿，太委屈曹真了。
曹叡的人设几近完美，时而镇定自若时而西斯底里，时而肝胆俱裂时而从容不迫。刘欢本剧演出堪比皇叔级别。
丁谧、何晏2位是配角，人设无功无过，演技食似鸡肋。
何驸马的演出还是容易让人跳戏。丁尚书中规中矩让人想到最早版本三国的标准演出，像一位古人。
曹爽，官拜大将军，曹氏氏族领袖，一人之下万人之上········································································································································································································································································································但是为什么他脑门上写着我无能，我贪婪，我没本事，我是官二代·············································································真的不配当仲达的对手，但又是这个不配当对手的对手把仲达逼的最惨·········这样的设定让我觉得司马二打赢了曹爽是应该的，没有那种胜利的酣畅··········
龙冥
