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急!求解释!

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急!求解释!


IP属地:北京来自iPhone客户端1楼2017-11-10 23:20回复
    SLC6A15 mRNA expression per rs1545843 genotype group measured in pre-mortem human hippocampus from individuals with temporal lobe epilepsy of European descent. (A) The MD risk genotype (AA) is associated with reduced full-length (FL, red boxes in part B) SLC6A15 mRNA expression levels compared to the non-risk genotypes (AG+GG). None of the other genes flanking the region of association with MD showed experiment-wide significant rs1545843 genotype-specific alterations in expression levels. SLC6A15 S: Short mRNA isoform of SLC6A15; (B) Box plot diagrams of FL (red) and S (blue) SLC6A15 mRNA expression levels in human hippocampus. On the x-axis the 3 genotype groups of rs1545843 are plotted against normalized SLC6A15 mRNA levels on the y-axis (group means: solid horizontal lines). Blue box-plots depict the expression levels of the short SLC6A15 isoform (S) and red plots expression levels of the full-length (FL) SLC6A15 transcript. For results of an analogues eQTL analysis in lymphoblastoid cell lines of HapMap individuals see supplemental fig. S3.


    IP属地:北京来自iPhone客户端2楼2017-11-10 23:20
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      Push


      IP属地:北京来自iPhone客户端3楼2017-11-10 23:27
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        喵,大概看了一下楼主的文章,是The neuronal transporter gene SLC6A15 confers risk to major depression这篇吧
        只能给楼主做参考,毕竟我只浏览了一下这张图,而且本人并不从事神经生物学或医学或基于人群的生物统计学。
        图片的意思是有MD风险的基因型AA( MD risk genotype AA, 自己翻译的不准确)与full length
        SLC6A15 mRNA 表达水平的降低有关联,而非风险的基因型AG, GG则没有。主要看图B,红色的盒形图是SLC6A15 mRNA 表达水平,每个盒中的粗黑线是平均值,可见AA的表达量会低一些。而short SLC6A15 mRNA表达水平和这几个基因型无关。
        图A应该是统计检验的结果,P<0.05表示有显著性差异。
        楼主是本科生么


        IP属地:美国4楼2017-11-11 10:37
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          圖a的slc6a15 fl,s,fl/s是想表達些甚麼?


          IP属地:北京来自iPhone客户端5楼2017-11-11 11:59
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            IP属地:北京来自iPhone客户端6楼2017-11-12 16:51
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              不好意思,人在国外很少看贴吧。
              p<0.05可以认为是存在差异,具体是什么解释需要看原文中用了什么统计方法
              理解p的意思需要了解一点生物统计学的知识
              红**ox是SLC6A15 FL表达水平,蓝**ox是SLC6A15 S表达水平


              IP属地:美国7楼2017-11-16 11:43
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