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Further information: Branched DNA and DNA nanotechnology
In DNA fraying occurs when non-complementary regions exist at the end of an otherwise complementary double-strand of DNA. However, branched DNA can occur if a third strand of DNA is introduced and contains adjoining regions able to hybridize with the frayed regions of the pre-existing double-strand. Although the simplest example of branched DNA involves only three strands of DNA, complexes involving additional strands and multiple branches are also possible.[69] Branched DNA can be used in nanotechnology to construct geometric shapes, see the section on uses in technology below.


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